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Long-term opioid misuse can lead to circumstances where the pain is completely uncontrollable

Early Signs of Vitamin D and B12 Deficiency The symptoms of Vitamin D and B12 deficiency often overlap, which makes proper testing important

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The lesion area was identified by the high cellular density (DAPI staining), abundance of microglia/macrophages (Iba1 + cells), and reduction of myelin content (using myelin oligodendrocyte glycoprotein, MOG) (Fig