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The structures of folic acid, MTX, and its three main metabolites are illustrated in Fig

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Together with opsonins, these antibodies facilitate the recognition of senescent RBCs by phagocytic cells, leading to their clearance predominantly in the spleen and liver as part of the reticuloendothelial system

Furthermore, when compared with isogenic wildtype control lines, even a low dose of the inhibitor CB-839 restored the radiation response of the KEAP1/NRF2 mutant cells