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The downstream effects are dramatic: keratinocyte proliferation and differentiation accelerate, the epidermis compacts and normalizes, melanin transfer is disrupted (fading pigmentation), and dermal fibroblasts are stimulated to produce new collagen while matrix-degrading enzymes (MMPs) are suppressed

In fact, in the CNS infiltrated peripheral myeloid cells, inflammatory signaling (pSTAT3) is significantly higher than in the CNS resident ones from the beginning to the peak of EAE (144)

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The band densities of the proteins of interest were quantified by the NIH Image J and normalized by corresponding total actin bands