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CNS Penetrant: Crosses the blood-brain barrier in preclinical models

The Faghihi 2021 study found that 0.6 mm performed equally well as 1.2 mm, suggesting shallower depths may be sufficient for some patients

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Trends Pharmacol Sci 37:6272 Lee JH, Chung YC, Bok E et al (2017) Injury-stimulated sonic hedgehog expression in microglia contributes to neuroinflammatory response in the MPTP model of Parkinsons disease

It works by upregulating growth factors your body already produces, particularly VEGF (which grows new capillaries) and growth hormone receptors in tendon and ligament tissue