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The cycle is completed when methionine is converted back into homocysteine, releasing SAMe, a very important methyl donor

BBB permeability alterations are often present before overt clinical symptoms, suggesting that BBB impairment may be a contributing factor to the pathogenesis of various neurological disorders (Figure 3)

LE/Lys are central trafficking hubs of the endosomal system, involved in sorting and degrading extracellular material and plasma-membrane bound molecules internalized by endocytosis, as well as intracellular components such as organelles via autophagy (Scott et al, 2014)

Protein-protein interaction network was derived using the IMex interactome database and visualized using Cytoscape software