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In a proof-of-concept clinical trial, supplementation of NAC in chronic schizophrenia patients ( N = 140) led to improvements of negative symptoms 17 , auditory mismatch negativity 18 , and local neural synchronization in electroencephalography (EEG) 19 as well as decreased side effects of antipsychotics 17

Homeodomain interacting protein kinase 2 (HIPK2) negatively regulates the expression of NMDAR subunit GluN2A and GluN2C and knockout of Hipk2 in the mouse brain increases the expression of GluN2A and thus the GluN2A/GluN2B ratio through altering JNK (c-Jun N-terminal kinase)-c-Jun signaling pathway [139]