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Specific objectives Primary objectives Measure whether daily maternal administration of 50 g vitamin B 12 from early pregnancy until 6 months postpartum improves cognitive, language and motor scores of the Bayley-III measured at 6 and 12 months of age

The trial portfolio included three single-dose pharmacokinetic studies and three multiple-dose efficacy trials

Serum B12 reference ranges vary between laboratories, but generally, levels below 148 pmol/L are considered deficient, whilst levels between 148258 pmol/L are regarded as borderline and may warrant further investigation or a trial of treatment, particularly if symptoms are present

Inner Circle members receive one complimentary B12 injection per month making monthly B12 maintenance free within the membership

In higher dose supplements, that percentage drops to 1%-2%