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In addition, activating KRAS mutations in non-small cell lung cancer (NSCLC), pancreatic and intestinal cancers enhance serine synthesis by increasing transcription of NRF2, a master regulator that promotes serine/glycine synthesis enzyme gene expression through ATF4 activation [9,10,11]

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Clause (i) of section 1886(m)(3)(A) of the Act provides for a reduction, for FY 2012 and each subsequent rate year, by the productivity adjustment described in section 1886(b)(3)(B)(xi)(II) of the Act