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These quinonemines (QIs) can rapidly and irreversibly modify proteins (Tingle et al., 1995

3.2.3.1 15q11-q13 The most common deletion/duplication syndrome associated with ASD phenotypes is the duplication syndrome of chromosome 15q11-q13.This region not only harbors the coding genes for GABA-A receptor 3 (GABRB3), 5 (GABRA5), and 3 (GABRG3) subunits but also serves as a genetic vulnerability hotspot due to its enrichment in low-copy repeats (LCRs)Deletions in the BP1-BP3 breakpoint regions are associated with ASD syndromes (64, 65)

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More serious but rare adverse events include pancreatitis (0.2% incidence), gallbladder disease requiring surgical intervention, and medullary thyroid carcinoma risk in genetically predisposed individuals (contraindicated in patients with personal or family history of MTC or MEN2 syndrome)