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This anti-apoptotic activity in lymphoid tissue contributes to preservation of immune system capacity during aging and environmental challenges

10.1186/s12906-017-2006-7 50 PanS.DengY.FuJ.ZhangY.ZhangZ.RuX.et al (2018)

Both activate AMPK, but through distinct mechanisms: metformin inhibits complex I of the mitochondrial electron transport chain, raising the cellular AMP:ATP ratio and thereby activating AMPK indirectly