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doi: 10.1073/pnas.1418973112 53

Histological analysis revealed more normal-like collagen architecturewith organized fiber patterns similar to unwounded dermis rather than the disorganized bundles typical of scar formation (Pickart et al., 2015)

While nicotine itself is not considered to be carcinogenic, each cigarette contains a mixture of carcinogens, including a small dose of polycyclic aromatic hydrocarbons (PAHs) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) among other lung carcinogens, tumor promoters, and co-carcinogens

A classic example is paclitaxel, which binds to -tubulin to stabilize microtubulesthis causes G2/M cell cycle arrest and triggers apoptosis (98)

Rivera-Diaz et al