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Collectively, these findings suggest although NF-B mediates the priming signal of NLRP3 inflammasome activation, induction of p62 expression and mitophagy by NF-B may serve as an autoregulatory mechanism to restrain its pro-inflammatory function

(1) BPC-157 has also been studied in correlation to gastrointestinal function

Ethics declarations Competing interests P.J.M

G.YuS.LiuY

Furthermore, they had cutaneous involvement, which is known to be associated with more rapidly progressive ILD and their disease was assessed to be active based on at least one marker of inflammation among CRP, platelets and ESR