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The crossover design strengthens the reliability of within-subject comparisons and offers robust insights into pharmacokinetic performance

Veronesi et al., 2015

RNAseq of PDX samples Total RNA was extracted from breast tumour xenografts samples by using miRNeasy Mini kit (#217004, Qiagen) according to the manufacturers procedure, treated by RNase-Free DNase (#79254, Qiagen), quantified and quality-controlled using a 2100 Bioanalyzer (Agilent)

Furthermore, the contributions of these different mechanisms may vary depending upon viral challenge dose, exposure conditions, nAb characteristics and a large number of other factors