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It is important to acknowledge the potential risk of bias in these dietary studies due to the inability to implement blinding

3.3 Inhibition of apoptotic pathways Apoptosis, a tightly regulated form of programmed cell death, plays a pivotal role in the ischemic penumbra-the metabolically compromised yet potentially salvageable region surrounding the infarct core (57, 58)

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2) Abnormally elevated CD163+ macrophages drive excessive complex phagocytosis, leading to macrophage iron overload, LIP expansion, oxidative stress, and ferroptosis

Biochem Cell Biol 68:11661173 Pavet V, Olmos E, Kiddle G, Mowla S, Kumar S, Antoniw J, Alvarez ME, Foyer CH (2005) Ascorbic acid deficiency activates cell death and disease resistance responses in Arabidopsis