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Although HNPs have direct and potent antimicrobial activities, 185 these peptides also control infection during acute infection by modulating various immune activities such as chemotaxis, phagocytosis, and cytokine induction

However, bTNF- increased lactate dehydrogenase subunit A (LDHA), IL-6, IL-8, IL-1 and COX-2 expression, which was dependent on glycolysis and the PI3K/Akt pathway