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Bromelain also caused high levels of ROS and superoxide, plus autophagosome and lysosome formation

Once the nucleus and cytoplasm boundaries were defined for each cell, the mean gray value was computed, representing the average gray value within the selected areas

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Trabolsi, A., Arumov, A

Consistent with this, our preclinical work uncovered that TMAO primed renal fibroblasts for conversion to myofibroblasts, the primary collagen-producing cells in the kidney 46 , and contributed to renal fibrosis, a hallmark of kidney damage irrespective of the underlying cause that significantly contributes to eGFR decline 46