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Following this concept, systematic, high-throughput lifespan studies in yeast using the H3/H4 histone mutant library showed that many histone residues, which can also bear modifications, could potentially affect lifespan, although still more in-depth studies are needed to better understand the aging effects of the associated PTMs (Sen et al., 2015)

Cerebellar modulation of human associative plasticity

92 showed that enzymatically increasing the NADH-to-NAD + conversion exclusively in the mitochondria of HeLa cells improves ETC function, highlighting the importance of maintaining high NAD + levels

2C and Table S3, respectively