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FDA CDER 2003 Bioavailability and Bioequivalence Studies for Nasal Aerosols and Nasal Sprays for Local Action (BA/BE Guidance): The definitive guidance for in vitro and in vivo studies required to demonstrate bioequivalence between a generic nasal spray and its Reference Listed Drug (RLD)

Its available in flakes, granules or powder form and is sprinkled over dishes or used to enhance the taste and texture of soups and sauces

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Xaa 8 is Ala, Gly, Vai, Leu, lie, Thr, Ser, Lys, a-aminoisobutyric acid, (l-aminocyclopropyl)carboxylic acid, (l-aminocyclobutyl)carboxylic acid, (l-aminocyclopentyl)carboxylic acid, (l-aminocyclohexyl)carboxylic acid, (l-aminocycloheptyl)carboxylic acid, or (l-aminocyclooctyl)carboxylic acid