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Pharmacological Research, 64 (2), 162-168

Retatrutide is a triple-receptor agonist (GLP-1, GIP, and Glucagon) that suppresses appetite, slows gastric emptying, and ramps up energy expenditure

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The CNS is particularly vulnerable to oxidative damage since it has a very active mitochondrial metabolism, which leads to high levels of intracellular superoxide anions