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Description

610 designed a selective KDM5C inhibitor with a triazole scaffold and subsequently synthesized a KDM5C degrader using PROTAC techniques

It keeps the enzymes in an active state by preventing the oxidation of sulfhydryl (-SH-) group of enzyme to disulfide (-s-s-) group

It can be a very effective long-term treatment for diabetic peripheral neuropathy (and other difficult-to-treat pain syndromes)

coli ATCC25922), meanwhile, LP1, WT1, and PT2 significantly increased weekly weight gain, villus height, antioxidant ability and gut microbiota diversity indexes in broilers