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In addition to its primary use for muscle spasms, Flexeril may also be prescribed off-label for certain conditions, such as fibromyalgia or chronic pain syndromes

The first generation of anti-tau antibodies, most of which targeted the proteins polymerization-driving N terminus, failed in clinical trials

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In addition, genetic ablation of the molecular clock in cardiomyocytes abolished this diurnal variation (Durgan et al., 2011)

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