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Description

This imbalance between sympathetic and parasympathetic activity leads to resting tachycardia, reduced HRV, orthostatic hypotension, and an increased risk of silent myocardial ischemia and sudden cardiac death

However, after a large dose of APAP, the sulfonation reaction becomes saturated and the build-up of NAPQI depletes GSH in the liver, causing further accumulation of NAPQI