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Mol Oncol 12(12):20422054 Lv X et al (2017) The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism

In SPMS, characterized by steady deterioration without acute attacks, treatment strategies often involve continuing or altering DMT used during the earlier RRMS phase, such as interferon beta, or considering immune-modulating agents, such as methotrexate, cyclophosphamide, or glucocorticoid pulses [142, 143]