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[17] The ratio of reduced glutathione to oxidized glutathione within cells is a measure of cellular oxidative stress [18] [11] where increased GSSG-to-GSH ratio is indicative of greater oxidative stress

Oxidative stress can lead to lipid peroxidation, a process in which ROS react with lipids in cell membranes, resulting in the formation of lipid peroxides and aldehydes such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) [9]

Sterile soil mitigates the intergenerational loss of gut microbial diversity and anxiety-like behavior induced by antibiotics in mice

Glutathione - Synthesis SFRBM Education Program Dickinson et al.5 + NADP NADPH Glutathione Reductase GSSG GSH Glutathione H O H O Peroxidase 2 2 2 LOH LOOH PSSP PSSG PSH Glutathione - redox cycling Glutathione - Synthesis SFRBM Education Program Dickinson et al.6 Glutathione uses and losses The glutathione S-transferases (GST) serve a protective role by adding GSH to a molecule, targeting it for export from the cell

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