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doi:10.1074/jbc.M408340200

When ROS reach high levels, they can cause major damage to various cellular components such as DNA, proteins, and lipids

Myofibroblast contributes to excessive collagen production in the atrial myocardium, leading to electrical/structural changes such as increased atrial stiffness, slow conductivity, formation of reentry circuits, and increased risk of ectopic activity, promoting and sustaining AF