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In support of this hypothesis, diminished expression of STIM and Orai proteins has been shown to be at the origin of decreased SOCE and increased resistance to oxidative damage in HT22 cells (Rao et al., 2013)

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68 Due to the beneficial effect of lymphangiogenesis in myocardial protection, it warrants additional studies to explore whether and how lymphangiogenesis contributes to exercised-induced cardiovascular protection