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Can a common ingredient in toothpaste cause tooth staining

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The AMPK pathway becomes active in response to insufficient cellular ATP levels which then leads to mTORC1 inhibition and diminished glutamine transporter expression

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Trends Neurosci 24:224230 Matute C, Alberdi E, Domercq M, Sanchez-Gomez MV, Perez-Samartin A, Rodriguez-Antiguedad A, Perez-Cerda F (2007) Excitotoxic damage to white matter