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In 2005, the result from a phase II open-label study demonstrated a satisfactory efficacy of RTX on pSS [28]

Renal function is associated with peak exercise capacity in adolescents with type 1 diabetes

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BiTEs exemplify this mechanism: their compact architecture favors tumor penetration and they indiscriminately engage CD3 T-cell subsetsincluding CD4, CD8, and Tregsthereby circumventing native T-cell receptor (TCR) specificity