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The tumor microenvironment represses T cell mitochondrial biogenesis to drive intratumoral T cell metabolic insufficiency and dysfunction

Nr1d1 (Rev-Erb), a circadian transcriptional repressor that coordinates mitochondrial metabolism, lipid synthesis, and inflammatory tone [82, 83], was upregulated across all exposures in both the PFC and NAc

When this was unclear, we considered a mortality rate higher than 5% (hospital mortality and if this was not reported we used ICU mortality or 28-day mortality) in the control group to be consistent with critical illness, c) intervention: parenteral GLN versus control (either isonitrogenous amino acid control) or placebo, d) study outcomes: must have included one of the following: mortality, ICU and hospital LOS, infectious complications, and other clinically important complications

Mechanism of Action How It Works in the Body 1

3.1.4.3 Strategies to bridge translational difficulties To improve clinical translatability, the following strategies are recommended: (1) Multi-species validation: mechanisms discovered in mice should be validated in rats, rabbits, or non-human primates