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glycolysis sustains phosphoinositide 3-kinase (PI3K) signaling and T-cell immunity 356

Another UPR branch is activated by IRE1, which following their dimerization and autophosphorylation 70 , generates a functional spliced XBP1 ( XBP1s ) 71 that as a transcription factor regulates the expression of numerous genes maintaining ER and metabolic homeostasis 7278 (Figure 2)

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