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This variability may stem from the complex feedback networks involving ROS-mediated redox and phosphorylation modifications (Su et al., 2019

Int J Cardiol 2013;168(3):2310-4

Among the various ROS, H 2 O 2 triggers the redox mechanism by targeting the receptor including protein tyrosine kinases, tyrosine phosphatases, and transcription factors via secondary messenger in intercellular signaling

The absorbance was measured at 450 nm using a Varioskan LUX microplate reader (Thermo Fisher Scientific, MA, USA)

Among these technologies, CRISPR-Cas9, currently the most advanced and widely applied gene editing tool, finds extensive use in ischemic stroke research