l carnitine supplement tmao γ-Butyrobetaine Is a Proatherogenic Intermediate in Gut Microbial Metabolism of L-Carnitine to Marked elevation in plasma trimethylamine-N-oxide

Methods Enzymol 77:237253 Lieberman MW, Wiseman AL, Shi ZZ, Carter BZ, Barrios R, Ou CN, Chevez-Barrios P, Wang Y, Habib GM, Goodman JC, Huang SL, Lebovitz RM, Matzuk MM (1996) Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice

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Upon cellular stimulation, Nrf2 dissociates from Kelch-like ECH-associated protein 1 (Keap1) and translocates from the cytoplasm to the nucleus to activate gene expression