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These three cell types contact each other directly, enhancing the relevance of BBB organoids, even if microglia and neurons, which also affect the BBB, are absent

Used mainly in research trials where chemical precision is crucial

In vitro studies have shown that intraduodenal instillation of soy protein hydrolysate (SPH) in weaned piglets promotes the release of anorexigenic hormones such as peptide YY (PYY) and glucose-dependent insulinotropic polypeptide (GIP), stimulates insulin production in pancreatic islet cells by elevating the level of GLP-1 to inhibit short-term feed intake and triggers the secretion of cholecystokinin (CCK) in the liver through activation of the CaSR and the intracellular Ca 2+ /TRPM 5 pathway to reduce the appetite of pigs (76)

doi: 10.3389/FIMMU.2023.1198365/XML 86 WingKOnishiYPrieto-MartinPYamaguchiTMiyaraMFehervariZet al

Note any deviations from the planned protocol immediately