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5 Hamilton B, Tol JL, Almusa E, Boukarroum S, Eirale C, Farooq A, Whiteley R, Chalabi H

The principal human curcumin metabolites following oral consumption are predominantly 4HC, 6HC, and glucuronide conjugates such as CG, 4HC-G, and 6HC-G (107, 108, 115)

They are classified as ROS and reactive nitrogen species (RNS) (De Gara and Foyer, 2017)

For the dose of CB-839 10 M, on average, 89% (range 79.2-92.7%) of HG-3 cells and 75% (range, 63-85,8%) of MEC-1 cells remained viable after 72 hours of incubation ( Figure 3B )