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Nolte Kennedy & Masharani, 2015)

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Copper (Cu) Copper is the 3rd most abundant trace element with only 75100 mg of the total amount in the human body [3]

Consistent with a role for plexins in the regulation of Ran, both proteins have been shown to share a role in the regulation of nucleocytoplasmic trafficking, mitotic spindle orientation [41, 42] and retrograde axonal endosomal transport [43, 44]