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Accordingly, in vivo administration of NAC attenuates the acute colitis through increased mucosal GSH levels, suggesting that GSH precursors may be of relevance in the acute relapse of IBD

From a clinical perspective, functional imaging of hypoxia, redox imbalance, and acidosis is increasingly being explored as part of a precision oncology framework

It is interesting to note that immune cells like microglia and macrophages shift from oxidative phosphorylation (typical of M2 type phenotype), which corresponds to an inactive state, to aerobic glycolysis (typical of M1 type phenotype), which corresponds to a proinflammatory state [41,42]