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Margittai , Enyedi B, Csala M, Geiszt M, Bnhegyi G

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Neurotrophic agents promote brain neuronal survival while decreases in their levels have been measured in several neurodegenerative diseases [55,56]

First, accessing new E3 ligases provides a strategy to address resistance mechanisms that are either already clinically observed or expected, particularly in oncology settings 16,17,18,19

"Deficiencies in inhibitory neurotransmission (e.g., glycine) can result in excessive excitation or reduced inhibition within neural pathways, resulting in seizures and epilepsy disorders."