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an FDA advisory review is scheduled for July 2026, with agency staff already recommending against approval

This adaptation can also contribute to resistance against therapies that induce oxidative stress or ferroptosis, supporting tumor growth and complicating treatment outcomes

While direct evidence from human clinical trials is currently limited, a study on donor selection for FMT in UC revealed that successful FMT donor microbiomes exhibited higher oxygen tolerance, indicating the importance of facultative anaerobes in re-establishing an anaerobic environment to counteract ROS (239)

Notably, WRKY70 was shown to determine the balance between SA-dependent and jasmonate-dependent defense pathways (Li et al., 2004, 2006)