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Description

Milk Thistle (Silybum marianum) is a flowering herb known for its liver-protective properties

To relieve this intrinsic autoinhibition and stabilise a productive binding interface for its substrates, two critical phosphorylation events are essential: autophosphorylation at serine 281 (S281) within the activation segment and transphosphorylation at threonine 444 (T444) within the C-terminal hydrophobic motif by upstream kinases [41,42,43,44]