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The newest class, rho kinase inhibitors like netarsudil , work by increasing trabecular outflow and represent a novel mechanism for IOP reduction

Finally, regarding interventions, clinical trials are frequently plagued by high heterogeneity, small sample sizes, short durations, and a lack of standardized adverse event reporting, resulting in a low certainty of evidence for most therapies and an inability to guide personalized care

The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications