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Parkinsonism Relat Disord 83:1521 [DOI] [PubMed] [Google Scholar] Christine CW et al (2018) Vitamin B12 and homocysteine levels predict different outcomes in early Parkinsons disease

Because B12 is water-soluble and excess is excreted in urine, there is no established tolerable upper intake level and no known risk of toxicity at standard supplement doses

Research and Regulatory Status Approved Use (Native IGF-1): The native recombinant human IGF-1 (Mecasermin) is FDA-approved for growth failure in children with severe IGF-1 deficiency