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Day 1: S1 + 3 M CHIR99021 (Peprotech, USA) + 100 ng/mL Activin A (Peprotech, USA) + 250 M vitamin C (Sigma Aldrich, USA)

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Sativex has undergone clinical testing as a potential treatment for neuropathic pain characterized by allodynia [85], diabetic neuropathy [86], and neuropathic pain associated with MS [77, 81, 82]