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Surgical Options In cases where conservative treatments fail to provide relief, surgical intervention may be necessary

This section presents an integrated perspective of how the epigenetic landscape collaboratively regulates intrinsic gene programs, drives cellular identity shifts and population evolution, and remodels the tumor microenvironment, thereby collectively constructing a robust and flexible resistance network (Fig

Overall, the conjugation of TKIs with HMCDs provides a novel approach to overcome the challenges associated with the use of TKIs in the treatment of brain tumors