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Oral supplementation (50150 g daily) may suit dietary deficiency without nerve involvement, but malabsorption cases require injections

In reality, many of these are still being evaluated, and their regulatory status is actively evolving

These models, which use laboratory toxicity data, were developed to predict the impact of oil constituents on standard or non-standard species (e.g., Interspecies Correlation Estimation or ICE models) or to estimate concentrations that are protective for 95% of the organisms (e.g., preparing species sensitivity distributions [SSDs] using CAFE)

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Supplier guidance often suggests using a small amount of a compatible organic solvent (e.g., DMSO or acetonitrile) for initial solubilization, then diluting into water/buffer